|
|
5alpha-pregnane-3beta-ol-20-one + NADP+ <=> H+ + 5alpha-dihydroprogesterone + NADPH
|
1.1.1.145
3beta-hydroxy-Delta5-steroid dehydrogenase
1.1.1.148
estradiol 17alpha-dehydrogenase
1.1.1.209
3(or 17)alpha-hydroxysteroid dehydrogenase
1.1.1.213
3alpha-hydroxysteroid 3-dehydrogenase (Re-specific)
1.1.1.270
3beta-hydroxysteroid 3-dehydrogenase
1.1.1.278
3beta-hydroxy-5alpha-steroid dehydrogenase
1.1.1.357
3alpha-hydroxysteroid 3-dehydrogenase
1.1.1.50
3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)
1.1.1.51
3(or 17)beta-hydroxysteroid dehydrogenase
|
–
–
–
–
–
–
–
–
–
|
| |
BRENDA:
BR47593;
BS187716
KEGG:
R07138;
R08957
MetaCyc:
1.1.1.278-RXN;
RXN66-567
SABIO-RK:
13071
|
|
|
|
5beta-Pregnan-3beta-ol-20-one + NADP+ <=> H+ + 5beta-pregnane-3,20-dione + NADPH
|
1.1.1.145
3beta-hydroxy-Delta5-steroid dehydrogenase
1.1.1.213
3alpha-hydroxysteroid 3-dehydrogenase (Re-specific)
1.1.1.270
3beta-hydroxysteroid 3-dehydrogenase
1.1.1.277
3beta-hydroxy-5beta-steroid dehydrogenase
1.1.1.50
3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)
1.1.1.51
3(or 17)beta-hydroxysteroid dehydrogenase
|
–
–
–
–
–
–
|
| |
BRENDA:
BR47374
KEGG:
R06166
MetaCyc:
1.1.1.277-RXN
SABIO-RK:
5749
|
|
|
|
digitoxigenin + reduced_[NADPH-hemoprotein_reductase] + O2 <=> gitoxigenin + oxidized_[NADPH-hemoprotein_reductase] + H2O
|
1.14.14.M47
|
–
|
| |
MetaCyc:
RXN-20962
|
|
|
|
5beta-pregnane-3beta,14beta-diol-20-one + reduced_[NADPH-hemoprotein_reductase] + O2 <=> 3beta,14beta,21-trihydroxy-5beta-pregnane-20-one + oxidized_[NADPH-hemoprotein_reductase] + H2O
|
1.14.14
|
–
|
| |
MetaCyc:
RXN-20956
|
|
|
|
5alpha-dihydroprogesterone + NADP+ <=> progesterone + NADPH + H+
|
1.3.1.22
3-oxo-5alpha-steroid 4-dehydrogenase (NADP+)
1.3.99.5
3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)
|
–
–
|
| |
BRENDA:
BS258427
KEGG:
R02208
MetaCyc:
PROGESTERONE-5-ALPHA-REDUCTASE-RXN
SABIO-RK:
2180
|
|
|
|
malonyl-CoA + 3beta,14beta,21-trihydroxy-5beta-pregnane-20-one <=> 3beta,14beta-dihydroxy-5beta-pregnane-20-one-21-O-malonylhemiester + CoA
|
2.3.1
|
–
|
| |
MetaCyc:
RXN-20960
|
|
|
|
3beta,14beta-dihydroxy-5beta-pregnane-20-one-21-O-malonylhemiester + H+ <=> (20,21)-dihydro-20-hydroxydigitoxigenin + CO2
|
not assigned
|
–
|
| |
MetaCyc:
RXN-20957
|
|
|
|
(20,21)-dihydro-20-hydroxydigitoxigenin <=> digitoxigenin + H2O
|
not assigned
|
–
|
| |
MetaCyc:
RXN-20958
|
|
|
|
5beta-Pregnan-3beta-ol-20-one + reduced_[NADPH-hemoprotein_reductase] + O2 <=> 5beta-pregnane-3beta,14beta-diol-20-one + oxidized_[NADPH-hemoprotein_reductase] + H2O
|
1.14.14
|
–
|
| |
MetaCyc:
RXN-20955
|
|
|
|
5beta-pregnane-3,20-dione + NADP+ <=> progesterone + NADPH + H+
|
1.1.1.213
3alpha-hydroxysteroid 3-dehydrogenase (Re-specific)
1.1.1.50
3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)
1.3.1.3
Delta4-3-oxosteroid 5beta-reductase
1.3.1.M16
1.3.99.6
3-oxo-5beta-steroid 4-dehydrogenase
|
–
–
–
–
–
|
| |
BRENDA:
BS389592
KEGG:
R02219
MetaCyc:
RXN-9726
SABIO-RK:
2191
|
|
